She worked at IBM in the 1960s and invented generalized dynamic instruction handling, a key advance used in out-of-order execution, used by most modern computer processors to improve performance. She initiated the Mead–Conway VLSI chip design revolution in very large scale integrated (VLSI) microchip design. That revolution spread rapidly through the research universities and computing industries during the 1980s, incubating an emerging electronic design automation industry, spawning the modern 'foundry' infrastructure for chip design and production, and triggering a rush of impactful high-tech startups in the 1980s and 1990s.[6][7][8][9][10]